Endocrine Abstracts

2-Methoxyoestrogens are emerging as a new class of anti-neoplastic agents. 2-Methoxyoestradiol (2-MeOE2), an endogenous oestrogen metabolite, has shown anti-proliferative effects in ER+ve and ER-ve breast cancer cell lines. In this study we have investigated the effects of sulphamoylated derivatives of 2-MeOE2, 2-methoxyoestradiol-3-O-monosulphamate (2-MeOE2MATE) and 2-methoxyoestradiol 3,17 bis sulphamate (2-MeOE2bisMATE) in ER-ve MDA-MB-231 cells. Both 2-MeOE2MATE and 2-MeOE...

Body composition using dual energy X-ray absorptiometry (DEXA) can be used as an specific method for measuring fat mass and identify individual risk for cardiovascular and metabolic complications in obese children.Objective: To investigate serum leptin level and its relationship with fat distribution in obese children.Materials and methods: Eighty-seven children (male/female=43/44, mean age 12.81±0.5 years). obese (BMI>95 ...

Introduction: Hashimoto thyroiditis (HT; with anti-thyroid peroxidase antibodies (TPOAb)) and Graves’ disease (GD; with TSH receptor antibodies (TRAbs)) are frequent autoimmune disorders responsible for thyroid dysfunction. There are two types of TRAbs, the ones that stimulate the thyroid (TSAb) causing Graves’ hyperthyroidism and those that block thyrotropin action (TBAb) being occasionally responsible for hypothyroidism. Unusual patients switch from TSAb to TBAb (o...

Nur77 is a nuclear orphan receptor belonging to the steroid receptor superfamily. A role for Nur77 has been described in proliferation, differentiation and apoptosis, as a result of its induction in response to multiple signal transduction pathways. Previous studies have suggested that physical interaction between Nur77 and the tumor suppressor p53 can prevent p53 ubiquination and subsequent degradation by hMdm2. This suggests a possible role for Nur77 as a regulator of p53-de...

It has been demonstrated that everolimus, an mTOR inhibitor, has potent anti-proliferative effect in a human Medullary Thyroid Carcinoma (MTC) cell line, TT, and in two human MTC primary cultures. We aimed at evaluating the possible antiproliferative effects of everolimus in a group of 20 human MTC in primary culture. To this purpose, 20 MTCs were dispersed in primary cultures, treated without or with 1 nM – 1 μM everolimus, 10 nM SOM230, and/or 50 nM IGF1. Cell viab...

Introduction: Using the criterion of GH<2.5 μg/l and normalized IGF1, response rates to currently available somatostatin analogues in medically-naïve patients with acromegaly are 20–25% after 12 m. The broader somatostatin receptor binding profile of pasireotide may potentially improve response rates. This randomized, double-blind 12-m study compared pasireotide LAR with octreotide LAR.Methods: Patients with acromegaly (GH>5 μ...

Background: Hyperinsulinemic hypoglycaemia (HH) after Roux-en-Y gastric bypass (RYGB) is rare. Patients typically present with post-prandial hypoglycaemia >1 year after surgery and once weight loss has plateaued. Despite multiple treatment options, the management of these patients remains challenging.Clinical case: A 31-year-old female was referred for bariatric surgery with a BMI of 41.4 kg/m2. In the year preceding the r...

Background: AMH represents a marker of ovarian reserve and is used in monitoring the effects of gonadotoxic drugs. In PCOS is higher and is an indirect marker of hyperandrogenism. In transsexual man(TM), high prevalence of PCOS is described and AMH provide information about ovarian reserve after exposure to testosterone.Objective: To assess the prevalence of PCOS in young TM previously to testosterone treatment, study the evolution of AMH levels and diff...

Amongst the different markers of ovarian function, AMH levels and antral follicle count (AFC) are the most objective and reliable predictors of ovarian response in women undergoing in-vitro fertilisation (IVF). Several factors, that have been reported to interfere with ovarian response, are taken into consideration when enrolling women into an IVF programme.The aim of this prospective study was to determine the correlation, if any, between baseline AMH l...

Patients with gonadotoxicity due to disease treatment, or who face primary gonadal insufficiency as a result of genetic causes, have limited options for long-term endocrine and fertility support. Current fertility options, such as egg or embryo banking, exclude women with hormone-responsive cancers and pre-pubertal children. This highlights the urgency of addressing this currently unmet need with innovative engineering solutions. Our objective is to create an ovary bioprosthes...